Water under the bridge

GraphicalAbstract_edited

Overview of features revealed by the new Hi-C maps. Left: there are at least six subcompartments, each bearing a distinctive pattern of epigenetic features and residing in its own nuclear neighborhood. Middle: the genome is folded up into small domains of condensed chromatin, whose median length is 185 kb. Right: the genome contains around 10,000 loops. These loops tend to lie at domain boundaries and bind the protein CTCF in a convergent orientation.Credit@SuhasRao/MiriamHuntley/ErezLiebermanAiden

Overview of features revealed by the new Hi-C maps. Left: there are at least six subcompartments, each bearing a distinctive pattern of epigenetic features and residing in its own nuclear neighborhood. Middle: the genome is folded up into small domains of condensed chromatin, whose median length is 185 kb. Right: the genome contains around 10,000 loops. These loops tend to lie at domain boundaries and bind the protein CTCF in a convergent orientation.Credit@SuhasRao/MiriamHuntley/ErezLiebermanAiden